Arthrosamid: The Science Behind a Groundbreaking Knee Osteoarthritis Treatment

Published at: 21/10/2023

Arthrosamid: The Science Behind a Groundbreaking Knee Osteoarthritis Treatment

Arthrosamid: The Comprehensive Treatment Guide for Knee Osteoarthritis

Arthrosamid, also known as Polyacrylamide (PAAG) hydrogel or simply PAAG, is a groundbreaking treatment for osteoarthritis (OA), particularly in the knee. This synthetic hydrogel offers a novel approach by adhering to and augmenting the synovial membrane, acting as a scaffold for tissue regeneration. With a favourable safety profile and promising patient-reported outcome measures (PROMs), Arthrosamid is gaining traction in the medical community.

The Science Behind Arthrosamid

Arthrosamid is a non-degradable and non-resorbable hydrogel composed of 2.5% cross-linked polyacrylamide and 97.5% non-pyrogenic water (McCollister et al., 1965). It is administered via intra-articular injection into the knee joint. The hydrogel serves as a scaffold for the synovial membrane, offering mechanical support and potentially aiding in the regeneration of damaged tissue.

Mechanism of Action

Arthrosamid adheres to the synovial membrane and acts as a physical buffer and scaffold. This allows for the integration of a de novo layer of infiltrating synovial lining cells (Henriksen et al., 2018; Tnibar et al., 2017; Christensen & Daugaard, 2016). lean more

Clinical Efficacy

  • 52-Week Prospective Study: A study by Henning Bliddal et al. showed significant improvements in knee OA symptoms after 52 weeks (OARSI CONNECT, 2021).
  • 6-Month Prospective Study: Another study indicated the efficacy of Arthrosamid in treating knee OA over a 6-month period (Gavin Publishers).
  • Reduction in Patellofemoral Bone Marrow Lesions: A study by Maulana R, Cole A, and Lee P.Y.F showed a reduction in patellofemoral bone marrow lesions following a single Arthrosamid intra-articular injection (Maulana et al., 2022).

Safety Profile

Arthrosamid has been well-documented for its safety. Overgaard A et al. published a retrospective case series confirming its safety for treating knee OA symptoms (Overgaard et al., 2019). No long-lasting adverse events have been reported in clinical studies (Henriksen et al., 2018).

A Systematic Review of the Novel Compound Arthrosamid Polyacrylamide (PAAG) Hydrogel for Treatment of Knee Osteoarthritis by Prof Lee's team learn more

Comparative Efficacy

Arthrosamid has shown numerically superior data compared to hyaluronic acid in terms of pain, stiffness, and physical function (Bliddal et al., 2018).

 Long-term Efficacy

The positive effects of Arthrosamid have been shown to last for at least 2 years (Medical Research Archives, 2022). learn more


Patient Stories: Real-world Experiences with Arthrosamid

Patient stories offer invaluable insights into the real-world applications and outcomes of Arthrosamid treatment for knee osteoarthritis. These testimonials provide a more personal perspective, complementing clinical studies and scientific data.

Treating an Olympic Star

An Olympic athlete who was suffering from knee osteoarthritis underwent Arthrosamid treatment. The treatment not only alleviated the athlete's pain but also improved their performance, allowing them to continue competing at the highest level. The athlete reported significant improvements in mobility and a reduction in discomfort during rigorous training sessions and competitions. Read more

Arthrosamid Olympic star


Treating a Leading GP in Harley Street

A leading General Practitioner based in Harley Street, renowned for medical excellence, opted for Arthrosamid treatment for their knee osteoarthritis. The GP reported remarkable improvements in daily activities and quality of life. The treatment allowed the GP to continue their demanding work schedule without the hindrance of knee pain. Read more

Additional Patient Stories

Various other patients have shared their positive experiences with Arthrosamid. These stories range from young adults to older individuals, all of whom reported significant improvements in their symptoms and overall well-being. The treatment has enabled them to return to their regular activities, whether it be sports, work, or daily tasks. Read more



Arthrosamid, also known as Polyacrylamide (PAAG) hydrogel, presents a promising and innovative treatment option for knee osteoarthritis. Its unique mechanism of action, involving the provision of a scaffold for the synovial membrane, offers a new avenue for tissue regeneration. Clinical studies and real-world patient stories corroborate its efficacy, safety, and long-term benefits. Comparative studies have also highlighted its superior performance against traditional treatments like hyaluronic acid. With a high level of confidence supported by extensive research and patient testimonials, Arthrosamid is poised to make a significant impact in the field of orthopaedic surgery and regenerative medicine.

AMSK Arthrosamid clinicarthrosamidreferences

Bliddal, H. et al., 2018. J Orthop Res Ther, 6, p.1188.  
Christensen, L. & Daugaard, S., 2016. Journal of Arthritis.  
Henriksen, M. et al., 2018. Clin Exp Rheumatol, 36(6), pp.1082-1085.  
Maulana, R., Cole, A. & Lee, P.Y.F., 2022. J Arthritis, 11 (3), pp.01-02.  
McCollister, D.D. et al., 1965. Toxicology and Applied Pharmacology, 7(5), pp.639-651.  
OARSI CONNECT, 2021. Poster 336.  
Overgaard, A. et al., 2019. Clin Ortho Adv Res J.  
Tnibar, A. et al., 2017. SM Journal of Biomedical Engineering, 3(3), p.1022.  
Medical Research Archives, 2022. [Online](  


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Prof. Paul Lee
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