Arthrosamid Efficiency Evidence & Clinical Trials Explained

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At MSK Doctors, we offer cutting-edge musculoskeletal (MSK) care with no need for GP referrals. Our team of leading orthopedic consultants specializes in sports injuries, joint pain, and advanced regenerative treatments, including SPAIRE Hip, BIKINI Hip, and Arthrosamid injections. We use a state-of-the-art musculoskeletal AI platform to gain valuable insights into movement patterns, helping us optimize treatment plans for better outcomes. 

With a 5-star Google rating, a comprehensive specialist directory to help you find the right expert, and a patient-centric approach, we’re here to empower you on your health journey. We also provide resources like downloadable materials, exercise guides, and self-care tips to support your recovery and well-being.

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Pain Reduction Data

Arthrosamid’s ability to significantly reduce pain in patients suffering from knee OA is its most compelling aspect. Clinical trials have demonstrated that patients experience a marked decrease in pain levels, which translates to a better quality of life. Most importantly, these effects are long-lasting.

For instance, a study conducted over a 3-year period by the NHS showed that patients reported consistent pain relief.  

Patient Function Improvement

Beyond pain reduction, Arthrosamid has also been shown to improve knee function - which is important because osteoarthritis often leads to decreased mobility, impacting daily activities and overall well-being. As such, Arthrosamid helps patients regain their independence and enjoy a more active lifestyle.

For example, in a 52-week study, patients reported improvements in joint stiffness and physical function. 

Long-term Efficacy

While many treatments offer temporary relief (e.g., you’ll usually need 3 hyaluronic acid injections to get only 6 months of knee OA pain relief), Arthrosamid provides sustained benefits.

Data from various clinical trials indicate that the positive effects of Arthrosamid can last for up to 3 years. This improves patient outcomes and also reduces the need for frequent interventions - making it a cost-effective option in the long run.

Clinical Trial Insights

There has been over 20 years of research in the making before Arthrosamid even received a CE mark for the symptomatic treatment of knee OA. Here’s a summary of the clinical trials: 

52-Week Prospective Study

• Authors/Publication: Henning Bliddal et al.

• Methodology: Multi-centre, open-label study, where 46 patients completed the study.

• Findings: The study reported significant improvements in knee OA symptoms 52 weeks after treatment with Arthrosamid.

6-Month Prospective Study

• Authors/Publication: Gavin Publishers.

• Methodology: Open-label study, where 48 patients completed the 13 and 46 the 26 weeks assessments.

• Findings: This research demonstrated the efficacy of Arthrosamid in treating knee OA over a 6-month period.

Reduction in Patellofemoral Bone Marrow Lesions

• Authors/Publication: Maulana R., Cole A., and Lee P.Y.F.

• Methodology: Just one 81-year-old woman.

• Findings: The study observed a reduction in patellofemoral bone marrow lesions following a single intra-articular (IA) injection of Arthrosamid.

ROSA 12-Month Study

• Authors/Publication: Poster 491 at OARSI 2022

• Methodology: Prospective, double-blind multicentre study, where 239 participants were randomized to either receive Arthrosamid or Synvisc-One injection. 

• Purpose: To compare the effectiveness of a single IA injection of polyacrylamide hydrogel (Arthrosamid) with that of a single injection of hyaluronic acid (Synvisc-One) in participants with moderate to severe knee OA.

• Findings: The study found that 74% of patients treated with Arthrosamid responded with a 40% improvement in WOMAC pain score. 

DAISY 13-Month Study

• Authors/Publication: Marius Henriksen et al. 

• Methodology: Prospective open-label cohort study on 84 patients. 

• Purpose: To identify the initial effectiveness of IA injection of iPAAG for the treatment of knee OA symptoms. 

• Findings: The study found significant reductions in WOMAC pain after 4 months. Most importantly, the effects were long-lasting for up to 13 months.

The graph above shows the changes in WOMAC pain subscale from baseline across different studies (image courtesy of Arthrosamid). 

Mode of Action Discussion

Mechanism of Arthrosamid

Arthrosamid is composed of 2.5% cross-linked polyacrylamide and 97.5% non-pyrogenic water. When injected into the knee joint, it acts as a cushioning agent, providing support and reducing friction between the bones. This cushioning effect helps in relieving pain and improving joint function.

Arthrosamid's ability to integrate with the synovial fluid and surrounding tissues as a scaffold contributes to its long-lasting effects. It remains stable within the joint, offering continuous support and relief.  

Comparative Analysis with Other Treatments

Traditional treatments like corticosteroid injections and hyaluronic acid provide temporary relief but often require repeated administrations while Arthrosamid's single-injection approach offers sustained results over several years.

Clinical trials have reported no serious adverse events, with any side effects - pain and swelling on the injection site - being mild and transient. This plus its effectiveness makes Arthrosamid a compelling option for patients and healthcare providers alike.

Proven Results for Your Peace of Mind

At MSK Doctors, we believe in offering treatments backed by robust clinical evidence. Arthrosamid's impressive 20-year research journey has culminated in multiple clinical trials demonstrating its effectiveness.

Our commitment to evidence-based care extends beyond just administering injections. We combine these proven treatments with our state-of-the-art Motion Artificial Intelligence (MAI) analysis to ensure precise delivery and optimal outcomes. This technology-driven approach, led by specialists like Professor Paul Lee, allows us to customize treatments to your specific needs and monitor your progress effectively.

When you choose MSK Doctors for your Arthrosamid treatment, you're getting a scientifically validated solution delivered by experts who understand both the technology and your needs. 

Ready to experience the benefits of this extensively researched treatment? Book your consultation today and join the growing number of patients who've found lasting relief through Arthrosamid at MSK Doctors.

Frequently Asked Questions (FAQ)

What is Arthrosamid?

Arthrosamid is an injectable hydrogel used to treat knee OA. Composed of 2.5% cross-linked polyacrylamide and 97.5% non-pyrogenic water, it acts as a cushioning agent within the joint, reducing pain and improving function without the need for surgery.

How effective is Arthrosamid for knee osteoarthritis?

Clinical trials have shown Arthrosamid to be highly effective in reducing pain and improving joint function in patients with knee OA. The treatment provides long-lasting relief, with effects sustained for up to three years or more, according to trial data.

What are the side effects of Arthrosamid?

In clinical trials, no serious adverse events were reported. Any side effects - discomfort, pain, and swelling at the injection site - were mild and transient, typically resolving without intervention. 

How long does the effect of Arthrosamid last?

The effects of Arthrosamid can last for several years, with clinical trial data indicating sustained pain relief and improved joint function for at least three years post-injection.  

How does MSK Doctors ensure optimal treatment outcomes?

MSK Doctors combines clinical expertise with cutting-edge Motion AI analysis for precise diagnosis and treatment delivery, backed by a team of leading specialists including Professor Paul Lee.