Prof. Paul Lee

Professor Paul Y F Lee is a Consultant Orthopaedic Surgeon, Medical Engineer, and Clinician Scientist, currently serving as Honorary Professor of Sports Medicine at the University of Lincoln’s College of Health and Science, and formerly Honorary Professor of Medical Engineering at the University of Chester. He holds a PhD in Medical Engineering, an MSc in Sports Medicine, and multiple surgical fellowships in regenerative orthopaedics, combining clinical experience with scientific innovation.
Uniquely positioned as both a medical doctor and an engineer, Professor Lee applies engineering principles to human biology and regeneration physiology, advancing the frontier of musculoskeletal medicine. He is internationally recognised for pioneering minimally invasive techniques and regenerative therapies that restore joint health, enhance recovery, and redefine surgical outcomes.
His surgical expertise spans a range of next-generation procedures, including STARR ACL repair, knee cap repair (Soft Tissue Augmentation Regenerative Repair), SPAIRE hip replacement, BIKINI hip replacement, and TWIS-TKR Knee Replacement. In parallel, he leads advancements in non-surgical treatments such as regenerative cell-based injections (mFat, PRP, PRF, Arthrosamid, and more....), which have become central to his biohacking and wellness-based approach to joint preservation and anti-ageing strategies.
Professor Lee is accredited by the International Cartilage Regeneration & Joint Preservation Society (ICRS) as a Teaching Centre of Excellence and is a member of the International Society for Cell & Gene Therapy. His research has been widely published, including studies on elite athletes and UK Premiership footballers, demonstrating significantly reduced recovery times through targeted, innovative treatments. He is an International expert on ACI, MACI, STACI.
Professor Lee’s dedication to research is reflected in over 100 peer-reviewed publications, 1,000+ citations, and multiple nationally competitive grants, including funding from Innovate UK and the Biomedical Catalyst. He also founded the MSK Computer Vision & AI Motion Lab, where he develops deep learning and AI tools to support diagnostics and personalised musculoskeletal care.
As Regional Surgical Advisor for the Royal College of Surgeons of Edinburgh, he is an active educator and mentor, supporting surgical training and academic growth for future clinicians. He is also the author of the Amazon best-selling book Regeneration by Design, which explores the science of healing, longevity, and regenerative biohacking.