Arthrosamid's Main Active Ingredients: How Exactly Does It Work?

Key Takeaways

• Arthrosamid is a non-degradable and non-resorbable hydrogel that’s composed of 2.5% cross-linked polyacrylamide and 97.5% non-pyrogenic water.

• The polyacrylamide acts as a scaffold, supporting the synovial membrane and promoting tissue regeneration.

• Non-pyrogenic water ensures the solution remains non-irritating and safe for joint injections.

• Clinical studies show Arthrosamid significantly reduces pain and improves joint function and is a viable alternative to hyaluronic acid for osteoarthritis symptoms.

• MSK Doctors provides same-day comprehensive care including MRI scans, motion analysis, and Arthrosamid injections, all supported by our cutting-edge AI technology.

Arthrosamid Composition

Arthrosamid (also known as intra-articular polyacrylamide hydrogel (iPAAG)) consists of two main components: polyacrylamide and non-pyrogenic water. This unique blend is what sets Arthrosamid apart from other osteoarthritis treatments. 

The image above shows the polyacrylamide hydrogel with a three-dimensional honeycomb structure. This structure is tight and uniform, allowing cells to grow within the matrix (image courtesy of Arthrosamid). 

More about Arthrosamid's composition: 

• It doesn’t contain any medicinal substances, tissues, or blood products. 

• The hydrogel integrates seamlessly with soft tissue, thanks to its permeability to salts and organic molecules. 

• Testing shows that it’s biocompatible and safe for long-term contact with the body.

• The cross-linked viscoelastic polymer chains offer flexible shear, ensuring smooth, adaptable movement.

• The hydrogel's non-degradable, stable structure delivers long-lasting effects without breaking down over time.

Role of Polyacrylamide

Polyacrylamide is a synthetic, biocompatible polymer that has the ability to form a gel-like structure when injected into the joint. Its cross-linked honeycomb structure provides a scaffold for the synovial membrane, aiding in the regeneration of tissue. This scaffold effect is crucial because it supports the natural healing processes within the joint, leading to improved mobility and reduced pain.

Importance of Non-Pyrogenic Water

The second ingredient, non-pyrogenic water, makes up the majority of the Arthrosamid solution. This type of water is free from fever-inducing contaminants, ensuring that the injection is safe and non-irritating. The water acts as a carrier for the polyacrylamide, allowing it to be evenly distributed throughout the joint to maximize the effects of polyacrylamide.

Mechanism of Action

Synovial Membrane Interaction

Once injected, the polyacrylamide gel integrates with the synovial membrane, which lines the joint - crucial as the synovial membrane plays a significant role in joint health, providing lubrication and nutrients to the cartilage. By serving as a scaffold, the polyacrylamide supports the synovial membrane, encouraging the growth of new synovial lining cells - which improves joint function and reduces inflammation.

Physical Buffer and Scaffold Functions

Besides supporting tissue regeneration, the polyacrylamide gel acts as a physical buffer within the joint, which helps absorb shock and reduce friction between the bones - especially beneficial for individuals with osteoarthritis. By minimizing wear and tear on the joint, Arthrosamid alleviates pain and even prevents further joint damage.

Effects on Knee Osteoarthritis

Symptom Improvement Studies

Clinical research has demonstrated that Arthrosamid effectively reduces symptoms associated with knee osteoarthritis. 

In a 52-week study, patients receiving Arthrosamid injections reported decreased pain and stiffness, alongside improved physical function. These results highlight the potential of Arthrosamid as a long-term solution for managing osteoarthritis symptoms.

Patellofemoral Bone Impact

The effects of Arthrosamid extend beyond symptom relief - it improves the knees physically too: 

• Reduces friction between the patella and femur.

• Improves joint alignment and movement.

• Decreases pressure on the patellofemoral joint, leading to less pain.

Clinical Efficacy

3-Year NHS Study

New data, first presented at the Annual Congress of Osteoarthritis Research International in March 2023, revealed impressive 3-year results. A single injection of 6 ml 2.5% polyacrylamide hydrogel remained well-tolerated and showed clinically relevant, statistically significant pain reduction even three years after treatment.

6-Month Study

A 6-month study conducted by Maulana R, Cole A, and Lee P.Y.F demonstrated a reduction in patellofemoral bone marrow lesions after a single intra-articular injection of Arthrosamid. This led to improvements in both joint pain and function. 

Safety Considerations

Documented Safety Profile

Arthrosamid's safety is well-documented, with clinical trials confirming its minimal risk of adverse effects. The non-pyrogenic water used in its formulation plays a key role in preventing irritation and ensuring a smooth, comfortable injection experience.  

Reported Adverse Events

Though Arthrosamid is generally well-tolerated, some patients may experience mild side effects, such as temporary swelling or discomfort at the injection site. These symptoms are typically short-lived and resolve without intervention. 

Most importantly, no long-term adverse events have been reported in clinical studies.

Comparative Performance

Comparison with Hyaluronic Acid

Hyaluronic acid has long been a staple in osteoarthritis management, but Arthrosamid offers several advantages. While both treatments aim to reduce joint pain, Arthrosamid provides longer-lasting relief due to its unique composition. The polyacrylamide gel remains active in the joint for extended periods, delivering sustained relief that surpasses the temporary benefits of hyaluronic acid.

Long-term Efficacy Analysis

When compared against Synvisc-One - which is a hyaluronic acid injection - Arthrosamid showed significant difference in change from baseline at 52 weeks.   

Patient Experience

General Feedback Overview

Feedback from Arthrosamid recipients has been overwhelmingly positive. Patients frequently report significant improvements in pain management and mobility, allowing them to participate in activities they once found challenging. 

Notable Patient Story

One of our patients who’s a notable Olympic swimmer, Sharron Davies MBE, visited us to heal her grade 4 bone-on-bone arthritis to her knee. 

Professor Paul Lee from MSK Doctors said that she could be a suitable patient to receive the Arthrosamid injection, which will improve symptoms and delay any knee surgery. Prof Lee performed an MRI scan, motion analysis, and Arthrosamid injection on Sharron, all on the same day. She was able to return to her daily life with much reduced pain. 

“I couldn’t believe how quick the procedure was, with very little discomfort and limited downtime. I was able to drive immediately. Pain can be really draining emotionally. Now, thanks to Arthrosamid, I feel more able to do the things I love with less pain of it. I’m very glad I gave it a try.” – Sharron Davies MBE

The Science Behind Long-Lasting Knee Pain Relief

At MSK Doctors, we understand that you’d want a knee osteoarthritis solution that lasts. Arthrosamid's unique composition of polyacrylamide and non-pyrogenic water creates a remarkable three-dimensional honeycomb structure that integrates seamlessly with your joint tissue, providing long-term relief from knee pain.

Our experience with Arthrosamid, supported by impressive clinical studies shows significant pain reduction that persists years after a single injection. What sets us apart is our comprehensive approach to treatment - from our state-of-the-art musculoskeletal AI analysis to same-day procedures, we ensure precise treatment delivery and optimal outcomes. 

Ready to experience the benefits of this innovative treatment? Book your consultation with MSK Doctors today, where you'll receive expert care without the wait times associated with GP referrals.

Frequently Asked Questions (FAQ)

What is the main ingredient in Arthrosamid?

The primary ingredient in Arthrosamid is polyacrylamide, a synthetic polymer which is biocompatible and has the ability to form a gel-like structure within the joint. This ingredient works as a scaffold to support the synovial membrane and promote tissue regeneration.

How does Arthrosamid provide relief in knee osteoarthritis?

Arthrosamid alleviates knee osteoarthritis symptoms by interacting with the synovial membrane and acting as a physical buffer. The polyacrylamide gel supports the membrane, aiding in the regeneration of synovial lining cells and improving joint function. This reduces inflammation and friction within the joint, leading to decreased pain and improved mobility.

Are there any side effects associated with Arthrosamid?

Arthrosamid is generally well-tolerated, with minimal side effects reported. Some patients may experience temporary swelling or discomfort at the injection site, which typically resolves without intervention.

How does Arthrosamid compare to other treatments?

Clinical studies have shown Arthrosamid to be superior in alleviating pain and improving mobility when compared to traditional treatments like hyaluronic acid.

What makes MSK Doctors a good choice for my Arthrosamid treatment?

MSK Doctors offer comprehensive same-day services including MRI scans, AI-powered motion analysis, and treatment by leading specialists like Professor Paul Lee. Our expertise and cutting-edge technology ensure precise treatment delivery and optimal outcomes without GP referral wait times.