Knee osteoarthritis is a common condition that affects many people and can have a significant impact on daily life and mobility. Recently, Arthrosamid injections have become an exciting, minimally invasive option to help relieve symptoms and improve joint function. This article offers clear, honest advice on what to expect after receiving an Arthrosamid injection, focusing on recovery and aftercare. Whether you are considering this treatment, preparing for the procedure, or in the early stages of recovery, the guidance here aims to provide reassurance and practical information. Professor Paul Lee, a specialist in cartilage health and Regional Surgical Ambassador, together with MSK Doctors — a trusted centre specialising in knee osteoarthritis care — offer expert insights throughout.

What to Expect Immediately After the Injection

Right after an Arthrosamid injection, it’s normal to feel some mild soreness, swelling, or stiffness in the knee. This swelling, often called “knee osteoarthritis swelling,” is your body’s natural response as it starts the healing process. These early sensations are usually mild and temporary, signalling that the treatment is beginning to take effect.

Importantly, clinical studies have shown that injecting Arthrosamid (a polyacrylamide hydrogel) into the knee is safe, with no lasting side effects reported. However, if you experience severe pain, excessive swelling, redness, or other unusual symptoms, don’t hesitate to get in touch with your healthcare provider. Knowing the difference between typical after-effects and warning signs helps you stay safe.

The First Week: Taking Care of Your Knee

During the first week after your injection, gentle care is key. While resting your knee is important, complete inactivity is not recommended. Light movement helps keep the joint flexible and encourages healthy blood flow. Applying ice packs, as advised by your clinician, can ease swelling and discomfort.

“Arthrosamid aftercare” often involves avoiding heavy lifting, strenuous exercise, or long periods of standing. Instead, focus on easy, everyday activities that don’t put too much strain on your knee. You may notice soreness peaking in the first few days and then gradually easing — this is typical and usually lasts about a week. Listen to your body and allow yourself to progress gradually.

How Pain Relief and Recovery Typically Progress

Pain relief after an Arthrosamid injection generally happens gradually. Everyone’s recovery, or “Arthrosamid injection recovery,” is unique — influenced by factors like the severity of osteoarthritis and overall health.

Many patients start to feel improvements within one to two weeks, with benefits continuing over several months. Research has found “statistically significant data at both 52 weeks and 13 months, indicating the lasting effectiveness of Arthrosamid at one year after treatment.” This shows the potential for sustained relief.

While it’s usually safe to resume light daily activities within the first week, returning to more demanding physical tasks, driving, or work should be done cautiously and with medical approval.

When compared with other knee injection treatments, such as hyaluronic acid or corticosteroids, Arthrosamid stands out. A recent study explained that “Arthrosamid offered comparable short-term results and a modest advantage at six months, especially compared to steroids, though it was similar to hyaluronic acid.” This means Arthrosamid may provide better medium-term relief than steroids and outcomes on par with hyaluronic acid, but long-term superiority is not firmly established. Whatever the treatment, following your clinician’s advice and pacing your recovery carefully is essential.

When to Seek Medical Advice

Although some mild soreness and swelling are expected after your injection, certain symptoms should prompt prompt medical attention. These include worsening or persistent pain, notable swelling or redness around the knee, and any fever or signs of infection. Getting timely advice helps prevent complications and supports safe healing.

Throughout your recovery, specialists such as Professor Paul Lee and the caring team at MSK Doctors are ready to support you. Their expertise in knee osteoarthritis means you are never alone with your questions or concerns.

In Summary

Most people experience only mild, short-lived symptoms following an Arthrosamid injection, with steady improvement as they follow aftercare guidance. Taking a slow and sensible approach to returning to normal activities will help you recover well.

If you have any doubts or questions during your recovery, reach out to your healthcare team, including experts like Professor Paul Lee and MSK Doctors. Their support and advice can make all the difference.

For personalised medical recommendations, always consult a qualified healthcare professional.

References

Cole, A., Maulana, R. K., Whitehead, J. P., & Lee, P. Y. F. (2022). A systematic review of the novel compound Arthrosamid polyacrylamide (PAAG) hydrogel for treatment of knee osteoarthritis. Medical Research Archives, 10(8). https://doi.org/10.18103/mra.v10i8.2950

Bliddal, H., Beier, J., Hartkopp, A., Conaghan, P. G., & Henriksen, M. (2023). Polyacrylamide hydrogel versus hyaluronic acid in knee osteoarthritis: a subgroup analysis of a randomised study. Orthopaedic Proceedings, 105-B(SUPP_13), 81–81. https://doi.org/10.1302/1358-992x.2023.13.081

Aykaç, B., Dinç, M., Nar, Ö. O., Karasu, R., & Bayrak, H. Ç. (2025). Comparative efficacy of polyacrylamide hydrogel versus hyaluronic acid and corticosteroids in knee osteoarthritis: A retrospective cohort study. Medicine, 104(38), e44655. https://doi.org/10.1097/md.0000000000044655