Published at: 17/12/2023


Lipogems: Advanced Fat Cell Therapy for Joint Health

At MSK Doctors, we are dedicated to providing groundbreaking treatments like Lipogems, a regenerative therapy using Microfragmented Adipose Tissue (MFAT) for osteoarthritis (OA) and other joint disorders. This technique, anchored in robust scientific research, leverages the inherent healing capabilities of your own fat cells.

The Science Behind Lipogems

Lipogems therapy is rooted in the innovative use of MFAT, demonstrating significant advancements in the treatment of OA and joint pain. Research, including a study cited on PubMed (Pubmed ID: 36541936), underscores the efficacy of MFAT in clinical and radiological improvements in knee OA. The LIPOGEMS device is instrumental in this process, ensuring the optimal preparation of MFAT.

How Lipogems Works

MFAT, as explained in studies like Heidari et al. (2020), operates through an MSC-related paracrine mechanism, promoting tissue regeneration and reducing pain by modulating inflammatory responses. This effect is not limited to knee OA; it also extends to conditions such as hip OA (Natali et al., 2022) and various musculoskeletal issues (Chirichella et al., 2019).

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The Lipogems Procedure

The procedure involves:

  1. Fat Tissue Harvesting: Performed under anaesthesia, fat tissue is carefully extracted.
  2. Tissue Processing: The LIPOGEMS system processes the fat to enrich it with MSCs.
  3. Targeted Injection: The prepared MFAT is injected into the affected joint to facilitate healing.

Broad-Spectrum Efficacy

Lipogems therapy is effective for:

  • Knee and hip OA
  • Cartilage, meniscus, and ligament injuries
  • Shoulder pain related to OA and rotator cuff issues

Integrative Treatment Approach

Lipogems can be effectively combined with other regenerative treatments like hyaluronic acid or platelet-rich plasma.

Clinical Validation and Safety

The safety and efficacy of Lipogems are supported by extensive research and clinical applications worldwide. Studies like Francesco et al. (2021) and Kaszyński et al. (2022), along with the PubMed reference (Pubmed ID: 36541936), provide a strong foundation for its use in improving joint function and alleviating pain.

Begin Your Journey to Improved Joint Health

Discover the potential of Lipogems at MSK Doctors. We are committed to offering innovative treatments and personalised care to help you regain a pain-free, active lifestyle.




  1. Chirichella, P., Jow, S., Iacono, S., Wey, H., & Malanga, G. (2019). Treatment of knee meniscus pathology: rehabilitation, surgery, and orthobiologics. Pm&r, 11(3), 292-308.
  2. Francesco, F., Gravina, P., Busato, A., Farinelli, L., Soranzo, C., Vidal, L., … & Gigante, A. (2021). Stem cells in autologous microfragmented adipose tissue: current perspectives in osteoarthritis disease. International Journal of Molecular Sciences, 22(19), 10197.
  3. Heidari, N., Noorani, A., Slevin, M., Cullen, A., Stark, L., Olgiati, S., … & Wilson, A. (2020). Patient-centered outcomes of microfragmented adipose tissue treatments of knee osteoarthritis: an observational, intention-to-treat study at twelve months. Stem Cells International, 2020, 1-8.
  4. Kaszyński, J., Bąkowski, P., Kiedrowski, B., Stołowski, Ł., Wasilewska-Burczyk, A., Grzywacz, K., … & Piontek, T. (2022). Intra-articular injections of autologous adipose tissue or platelet-rich plasma comparably improve clinical and functional outcomes in patients with knee osteoarthritis. Biomedicines, 10(3), 684.
  5. Molnar, V., Pavelić, E., Jeleč, Ž., Brlek, P., Matišić, V., Borić, I., … & Primorac, D. (2022). Results of treating mild to moderate knee osteoarthritis with autologous conditioned adipose tissue and leukocyte-poor platelet-rich plasma. Journal of Personalized Medicine, 13(1), 47.
  6. Natali, S., Screpis, D., Romeo, M., Magnanelli, S., Rovere, G., Andrea, A., … & Zorzi, C. (2022). Is intra-articular injection of autologous micro-fragmented adipose tissue effective in hip osteoarthritis? a three year follow-up. International Orthopaedics, 47(6), 1487-1492.
  7. Xiong, M., Zhang, Q., Hu, W., Zhao, C., Lv, W., Yi, Y., … & Wu, M. (2020). Exosomes from adipose-derived stem cells: the emerging roles and applications in tissue regeneration of plastic and cosmetic surgery. Frontiers in Cell and Developmental Biology, 8.
  8. Fan F, Grant RA, Whitehead JP, Yewlett A, F Lee PY. An observational study evaluating the efficacy of microfragmented adipose tissue in the treatment of osteoarthritis. Regen Med. 2023 Feb;18(2):113-121. doi: 10.2217/rme-2022-0110. Epub 2022 Dec 21. PMID: 36541936.

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About Authors
Prof. Paul Lee
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Experts in Stem Cell - Fat Cells
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