Platelet Rich Fibrin (PRF): Purpose, Benefits, Side Effects, Cost, Time to Work

Ms. Thula Chelvan
Published at: 11/4/2024

Platelet Rich Fibrin (PRF): Purpose, Benefits, Side Effects, Cost, Time to Work

Key Takeaways

  • Platelet Rich Fibrin (PRF) is a potent regenerative therapy that promotes healing and tissue growth by harnessing the body's own healing factors concentrated from one’s own blood.
  • PRF offers benefits such as faster healing, decreased inflammation, and cost-effectiveness.
  • Though generally safe, PRF therapy can have side effects that are usually minor and manageable such as temporary swelling, redness, or bruising at the injection site.
  • The cost of PRF treatment can vary (from $700 to $3,000) but is often more affordable than other regenerative therapies.
  • PRF starts to work shortly after treatment, with continued improvements over time.

What Is The Purpose of Platelet Rich Fibrin?

Platelet Rich Fibrin, or PRF, is a second-generation platelet concentrate. It's basically a substance made from your own blood that's rich in platelets, growth factors, white blood cells, and fibrin, all of which are crucial for healing. When applied to an injury, PRF releases these growth factors over time, supporting the body's natural healing process.

Conditions That PRF Can Be Used to Treat 

PRF's efficacy lies in its ability to accelerate wound healing and promote tissue regeneration. PRF boosts the body's own repair mechanisms, making it easier to heal bones, muscles, tendons, and even skin. It’s especially effective for conditions such as:

  • Chronic Wounds: PRF injections have proven particularly effective in facilitating the closure of chronic wounds such as diabetic foot ulcers, pressure sores, and surgical wounds with delayed healing. The concentrated growth factors stimulate cellular proliferation and blood vessel formation, creating an optimal environment for tissue repair and wound closure.

  • Sports Injuries: Athletes are susceptible to repetitive strain injuries like tendonitis, ligament sprains, and muscle tears. PRF therapy can significantly shorten recovery times by promoting tissue repair and reducing inflammation. This allows for a faster return to play and potentially reduces the risk of re-injury.

  • Osteoarthritis: PRF injections also offer significant pain relief and improved joint function for patients with osteoarthritis. The growth factors within PRF stimulate the production of healthy cartilage and reduce inflammation within the joint, leading to increased mobility and a better quality of life.

Platelet Rich Fibrin (PRF) Purpose, Benefits, Side Effects, Cost, Time to Work

How PRF Stands Out from Other Treatments

PRF is made from your own blood. This ensures it is naturally accepted by your body and lowers the chance of rejection or complications that can come with foreign substances.

Additionally, the fibrin matrix of PRF acts as a framework that encourages and guides the growth of new tissue, which sets it apart in the realm of regenerative medicine.

Platelet-Rich Fibrin (PRF) vs Platelet-Rich Plasma (PRP) 

Though both PRF and PRP are derived from the patient’s blood, there are some differences between them. Here’s an overview of their differences:


Platelet-Rich Fibrin (PRF)

Platelet-Rich Plasma (PRP)


Higher concentration of platelets, leukocytes, and fibrin

Higher concentration of platelets and growth factors

Growth Factor Release

Slower release of growth factors

Faster release of growth factors

Clinical Applications

Beneficial for tissue regeneration and healing

Popular for various clinical applications, including MSK related issues


$700 to $3000 per treatment

$500 to $2000 per treatment

Benefits of Platelet Rich Fibrin

Quick Recovery

The major advantage of PRF is its ability to speed up the tissue healing process. The growth factors in PRF initiate tissue repair, meaning you can return to your normal activities sooner. This is particularly important for athletes or anyone looking who is intentional about quick tissue recovery.

Improved Tissue Healing

PRF typically aids in the construction of stronger, healthier tissues. PRF promotes the development of new cells, whether in bone, muscle, or skin, resulting in more comprehensive and robust healing.

Less Inflammation and Pain

Managing inflammation and pain can be a struggle. Luckily, PRF can help to ease these symptoms by adjusting the body's inflammatory response. This results in less pain and more comfort during the healing phase.

Better Safety and Cost-Effectiveness

PRF is a procedure that uses your own blood, making it safer and less likely to cause complications compared to other treatments. In terms of cost, PRF is usually cheaper than surgery or long-term medication.

Potential Side Effects of PRF

PRF is typically seen as safe, but it's crucial to know about possible side effects, even if they're uncommon. These could be an infection at the spot of injection, discomfort or inflammation, and in extremely rare cases, a reaction to the anticoagulant used in the making of PRF. Don't worry, these risks are very low when the procedure is done by a certified health practitioner in a clean setting.

Primarily, the risk of complications is much less with PRF than with surgery, because PRF is a minimally invasive procedure that uses the body's own healing mechanisms. So, although there maybe a chance of complications, they are rare and usually the benefits of faster healing and tissue regeneration outweigh them.

Cost of Platelet Rich Fibrin

The cost of PRF therapy may cost anywhere from $700 to $3,000, depending on how much treatment you need.

Moreover, it is important to mention that PRF could be a more affordable alternative in the long run compared to other treatments, especially when you take into account the possibility of a quicker recovery and the decreased likelihood of needing more procedures.

How PRF Costs Stack Up Against Other Treatments

For a clearer understanding of PRF costs, you may need to know that surgical options can be quite pricier and come with longer recovery periods and higher risks. On the other hand, PRF therapy is a less invasive and more natural method, often leading to a more affordable solution over time.

How Long Does It Take for PRF to Work?

Although there isn't a set timeline for healing with PRF, some people might start to feel better within a week, while others might not see the full effects for several months. The body's response to PRF can depend on things like the person's overall health, how severe their condition is, and how fast their body naturally heals.

What Influences the Effectiveness of PRF?

The effectiveness and results of PRF therapy can be affected by a variety of factors such as thepatient's age, lifestyle, diet, the seriousness of the injury, and how closely they follow the care instructions after treatment. To get the most healing benefits from PRF, it's crucial to closely follow the advice of the healthcare provider.

MSK Doctors For Your Platelet Rich Fibrin

At MSK Doctors, we are dedicated to providing excellent care, educating our patients, and offering access to the best musculoskeletal specialists. We know the difficulties that come with musculoskeletal conditions and are committed to helping you start your recovery process with the cutting-edge technology of PRF therapy.

Don't allow pain in your bones, joints, ligaments, or tendons to control your life. Our professionals are on standby to assist you in attaining the best healing experience. Get in touch with us now and start your journey to recovery with assurance. You may also give us a call at +4403300010048 to get started.

Frequently Asked Questions (FAQ)

What are the Applications of Platelet Rich Fibrin?

Platelet Rich Fibrin (PRF) therapy is a flexible treatment option that can be used for a variety of musculoskeletal conditions. This includes, but is not limited to, injuries to the tendons, osteoarthritis, surgical wounds, and fractures in the bones. The growth factors found in PRF help to speed up the process of tissue healing, making it a viable option for many patients.

PRF therapy can help speed up recovery times and improve the final results by enhancing the body's natural healing processes. Whether you've suffered a sports injury or are recovering from surgery, PRF could be a helpful part of your treatment plan.

Does Platelet Rich Fibrin Therapy Hurt?

PRF therapy is a minimally invasive treatment that most patients find bearable. While some people may feel a slight discomfort during the blood draw or injection, the pain is usually brief and manageable.

Most people say that PRF therapy doesn't cause much pain, and if you do feel any discomfort, you can usually relieve it with over-the-counter painkillers. Your specialist will talk to you about how to manage any pain to make sure you're comfortable.

How Frequently Can I Get Platelet Rich Fibrin Treatments?

The number of PRF treatments you can receive depends on your personal health status and the treatment plan your healthcare provider recommends. Some patients may see a lot of improvement with just one treatment, while others may need several sessions to get the results they want.

During your initial meeting, your healthcare provider will create a custom treatment plan that meets your recovery objectives. It's crucial to adhere to their recommendations to fully benefit from PRF treatments.

Is it Possible to Combine Platelet Rich Fibrin with Other Treatments?

Indeed, PRF therapy is frequently used in conjunction with other treatments to improve healing. For example, it can be used in combination with physical therapy, medication, or other regenerative treatments such as stem cell therapy.

Your doctor will take into account your full treatment plan to decide on the best mix of treatments to aid your recovery. Using PRF in conjunction with other treatments can result in more complete and successful results.

Who Should Not Use Platelet Rich Fibrin?

PRF therapy is not for everyone. It may not be suitable for people with active infections, certain blood disorders, or those who are on certain medications that affect blood clotting.

During your consultation, it's important to share your full medical history with your healthcare provider. This will allow them to determine if PRF treatment is a good and safe option for you.

More Articles
All Articles